Molecular regulation of T‐cell anergy

Molecular regulation of T-cell anergy.

The activation of T cells is tightly controlled by many positive and negative regulatory processes. This fine-tuning allows productive immunity to pathogens while minimizing the risk of autoimmunity. One negative regulatory mechanism is clonal anergy, which is a hyporesponsive state that occurs when T cells are activated through the T-cell antigen receptor in the absence of appropriate co-stimu...

Sensors, and Epigenetic Imprinting Cell Anergy: Anergy Factors, Avoidance New Insights into the Molecular Basis of T

Epigenetic regulation of tumor endothelial cell anergy: silencing of intercellular adhesion molecule-1 by histone modifications.

Tumors can escape from immunity by repressing leukocyte adhesion molecule expression on tumor endothelial cells and by rendering endothelial cells unresponsive to inflammatory activation. This endothelial cell anergy is induced by angiogenic growth factors and results in reduced leukocyte-vessel wall interactions, thereby attenuating infiltration of leukocytes into the tumor. This report descri...

Noncoding transcription controls downstream promoters to regulate Tcell receptor recombination

The T early a (TEA) promoter in the murine Tcra locus generates noncoding transcripts that extend across the 65kb Ja array. Here, we have analyzed the significance of TEA transcription for Tcra locus regulation through the targeted introduction of a transcription terminator downstream of the TEA promoter. We demonstrate that noncoding transcription driven by this single promoter can instruct bo...

a tripartite model of efl teachers attributions, burnout, and ‎self-regulation: towards the prospects of effective teaching

همطالعه حاضر به ارائه مدلی برای آموزش موثر زبان انگلیسی ‏می پردازد. مدل حاضر از سه عامل تاثیر گذار در کارایی ‏تدریس معلمان زبان انگلیسی بهره می برد. این سه عامل شامل ‏سبکهای اسنادی، خود تنطیمی و فرسودگی شغلی معلمان ایرانی ‏زبان انگلیسی می باشد. رساله مورد نظر درچهار فاز طراحی ‏شده است: فاز اول شامل طراحی و رواسازی پرسشنامه سبکهای ‏اسنادی معلمان زبان انگلیسی و فاز دوم شامل استفاده از ‏این پرسشنا...